The Myo1G Polyclonal Antibody (PAC046046) is a powerful tool for researchers studying Myo1G, a motor protein involved in cellular processes such as cell motility and intracellular transport. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blotting applications. By targeting the Myo1G protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an ideal choice for investigations in cell biology and cancer research.
Myo1G, also known as Myosin IG, is a key player in maintaining cellular structure and function by facilitating the movement of cellular components. Its role in cellular dynamics makes it a promising target for studying various diseases, including cancer and neurological disorders. Understanding the function of Myo1G can provide valuable insights into the mechanisms underlying these conditions and may lead to the development of therapeutic interventions that target this motor protein.
Immunohistochemistry of paraffin-embedded human lymph node tissue using PACO46046 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO46046 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human appendix tissue using PACO46046 at dilution of 1:100.
Background:
Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-γ receptor (Fc-gamma-R) phagocytosis.
MYO1G: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Contractile; MotorChromosomal Location of Human Ortholog: 7p13Cellular Component: membrane; phagocytic cup; plasma membraneMolecular Function: phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate bindingBiological Process: T cell mediated immunity
UniProt Protein Details:
NCBI Summary:
MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]
