MYLK Rabbit Polyclonal Antibody (CAB8041)
- SKU:
- CAB8041
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | MYLK Rabbit Polyclonal Antibody |
SKU: | CAB8041 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1765-1914 of human MYLK (NP_444253.3). |
Sequence: | SGLS GRKS STGS PTSP LNAE KLES EEDV SQAF LEAV AEEK PHVK PYFS KTIR DLEV VEGS AARF DCKI EGYP DPEV VWFK DDQS IRES RHFQ IDYD EDGN CSLI ISDV CGDD DAKY TCKA VNSL GEAT CTAE LIVE TMEE GEGE GEEE EE |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 |
Synonyms: | KRP; AAT7; MLCK; MLCK1; MMIHS; MYLK1; MMIHS1; MYLK-L; smMLCK; MLCK108; MLCK210; MSTP083; MYLK |
Positive Sample: | HeLa,HepG2,HT-1080 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell projection, Cleavage furrow, Cytoplasm, cytoskeleton, lamellipodium. |
Calculated MW: | 211kDa |
Observed MW: | Refer to figures |
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.
Purification Method: | Affinity purification |
Gene ID: | 4638 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |