Myelin Protein Zero (MPZ) Monoclonal Antibody (CAB21931)
The Myelin Protein Zero (MPZ) Monoclonal Antibody is a cutting-edge tool designed for research involving the MPZ protein, which plays a crucial role in peripheral nerve myelination. The monoclonal antibody, raised in mice, is highly specific and reliable for detecting MPZ in human samples, making it an invaluable asset for studies in neurology and neuroscience.MPZ, also known as P0 protein, is a major component of myelin in the peripheral nervous system, essential for the insulation and proper functioning of nerve fibers. Dysregulation or mutations in the MPZ gene have been linked to various neurological disorders, including Charcot-Marie-Tooth disease and other demyelinating neuropathies.
Therefore, studying MPZ expression and function is instrumental in understanding the pathophysiology of these diseases and developing potential therapeutic interventions.With its high sensitivity and specificity, the Myelin Protein Zero Monoclonal Antibody is a versatile tool for researchers seeking to explore the role of MPZ in nerve myelination, nerve regeneration, and neurodegenerative diseases. Its applicability in techniques such as Western blotting, immunohistochemistry, and immunofluorescence makes it an indispensable reagent for investigations into the molecular mechanisms underlying peripheral nerve disorders.
Product Name:
Myelin Protein Zero (MPZ) Monoclonal Antibody
SKU:
CAB21931
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 149-248 of human Myelin Protein Zero (MPZ) (NP_000521.2).
Cell membrane, Myelin membrane, Single-pass type I membrane protein.
Calculated MW:
28kDa
Observed MW:
28kDa
This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.
Purification Method:
Affinity purification
Gene ID:
4359
Clone Number:
ARC53696
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Myelin Protein Zero (MPZ) Rabbit mAb (CAB21931) at1:19000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
