Myelin Protein Zero (MPZ) Monoclonal Antibody (CAB21931)
- SKU:
- CAB21931
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | Myelin Protein Zero (MPZ) Monoclonal Antibody |
SKU: | CAB21931 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 149-248 of human Myelin Protein Zero (MPZ) (NP_000521.2). |
Sequence: | KVPT RYGV VLGA VIGG VLGV VLLL LLLF YVVR YCWL RRQA ALQR RLSA MEKG KLHK PGKD ASKR GRQT PVLY AMLD HSRS TKAV SEKK AKGL GESR KDKK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:2000 - 1:20000 |
Synonyms: | P0; CHM; DSS; MPP; CHN2; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; HMSNIB; Myelin Protein Zero (MPZ) |
Positive Sample: | Mouse Spinal cord,Mouse Skeletal muscle,Rat Skeletal muscle |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Myelin membrane, Single-pass type I membrane protein. |
Calculated MW: | 28kDa |
Observed MW: | 28kDa |
This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.
Purification Method: | Affinity purification |
Gene ID: | 4359 |
Clone Number: | ARC53696 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |