MPZ Rabbit Polyclonal Antibody (CAB1687)
- SKU:
- CAB1687
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | MPZ Rabbit Polyclonal Antibody |
SKU: | CAB1687 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-153 of human Myelin Protein Zero (MPZ) (NP_000521.2). |
Sequence: | IVVY TDRE VHGA VGSR VTLH CSFW SSEW VSDD ISFT WRYQ PEGG RDAI SIFH YAKG QPYI DEVG TFKE RIQW VGDP RWKD GSIV IHNL DYSD NGTF TCDV KNPP DIVG KTSQ VTLY VFEK VPTR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | P0; CHM; DSS; MPP; CHN2; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; HMSNIB; Myelin Protein Zero (MPZ) |
Positive Sample: | Mouse spinal cord,Rat brain,PC-12 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Myelin membrane, Single-pass type I membrane protein. |
Calculated MW: | 28kDa |
Observed MW: | 28kDa |
This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.
Purification Method: | Affinity purification |
Gene ID: | 4359 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |