The Myelin Protein P0 Polyclonal Antibody (CAB1687) is a valuable tool for researchers studying myelin protein P0, a major structural component of peripheral nervous system myelin. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it suitable for various immunological applications.Myelin protein P0 is essential for the formation and maintenance of myelin sheaths, which are crucial for proper nerve impulse conduction. Dysregulation or mutations in this protein have been implicated in various neurological disorders, such as Charcot-Marie-Tooth disease.
This antibody enables researchers to study the expression and localization of myelin protein P0 in different cell types and tissues, providing valuable insights into the role of this protein in normal physiology and disease pathology. Its use in Western blot applications allows for accurate detection and quantification of myelin protein P0 levels, making it a versatile tool for neuroscience and neurology research.
Product Name:
MPZ Rabbit Polyclonal Antibody
SKU:
CAB1687
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-153 of human Myelin Protein Zero (MPZ) (NP_000521.2).
P0; CHM; DSS; MPP; CHN2; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; HMSNIB; Myelin Protein Zero (MPZ)
Positive Sample:
Mouse spinal cord,Rat brain,PC-12
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Myelin membrane, Single-pass type I membrane protein.
Calculated MW:
28kDa
Observed MW:
28kDa
This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.
Purification Method:
Affinity purification
Gene ID:
4359
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse spinal cord, using Myelin Protein Zero (MPZ) antibody (CAB1687) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
