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Myelin Basic Protein/MBP Polyclonal Antibody

SKU:
CAB24860
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IHC
IF
€129 - €359
Frequently bought together:

Description

Myelin Basic Protein/MBP Polyclonal Antibody (CAB24860)

The Myelin Basic Protein (MBP) Polyclonal Antibody is a valuable tool for researchers studying myelin-related disorders, such as multiple sclerosis. This antibody, raised in rabbits, enables specific detection of the MBP protein in various cell types, making it ideal for immunohistochemistry and Western blot applications.Myelin Basic Protein is a key component of the myelin sheath that surrounds nerve fibers in the central nervous system. Dysfunction of the myelin sheath is associated with a range of neurological disorders, making MBP an important target for research in neurology and neuroscience.

By utilizing the Myelin Basic Protein Polyclonal Antibody, researchers can gain insights into the role of MBP in myelin formation, maintenance, and repair. This antibody's high reactivity with human samples and validation for specific applications make it a reliable tool for investigating the molecular mechanisms underlying myelin-related diseases and exploring potential therapeutic interventions.

Product Name:Myelin Basic Protein/MBP Polyclonal Antibody
Product Code:CAB24860
Reactivity:Mouse, Rat
Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Mouse, Rat
Tested Applications:WB, IHC-P, IF/ICC
Key Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Recommended Dilution:WB 1:500-1:1000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:Mouse brain
Cellular Location:Cytoplasmic side, Myelin membrane, Nucleus, Peripheral membrane protein

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-304 of human Myelin Basic Protein/MBP (NP_001020272.1).
Sequence:MGNHA GKREL NAEKA STNSE TNRGE SEKKR NLGEL SRTTS EDNEV FGEAD ANQNN GTSSQ DTAVT DSKRT ADPKN AWQDA HPADP GSRPH LIRLF SRDAP GREDN TFKDR PSESD ELQTI QEDSA ATSES LDVMA SQKRP SQRHG SKYLA TASTM DHARH GFLPR HRDTG ILDSI GRFFG GDRGA PKRGS GKDSH HPART AHYGS LPQKS HGRTQ DENPV VHFFK NIVTP RTPPP SQGKG RGLSL SRFSW GAEGQ RPGFG YGGRA SDYKS AHKGF KGVDA QGTLS KIFKL GGRDS RSGSP MARR
Synonyms:MBP, myelin basic protein
Calculated MW:17kDa/18kDa/20kDa/21kDa/33kDa
Observed MW:17-33kDa

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