The MYD88 Polyclonal Antibody (CAB16889) is a valuable tool for researchers studying MYD88, a key adapter protein involved in signaling pathways associated with inflammation and immune responses. This antibody, developed using rabbits, is highly specific to human samples and has been validated for use in Western blot applications.MYD88 plays a crucial role in the activation of the NF-κB signaling pathway, leading to the production of pro-inflammatory cytokines and the regulation of immune responses. Dysregulation of MYD88 signaling has been implicated in various diseases including cancer, autoimmune disorders, and infectious diseases.
The MYD88 Polyclonal Antibody enables researchers to detect and analyze MYD88 protein expression in different cell types, providing valuable insights into the molecular mechanisms driving these disease processes.With its high reactivity and specificity, the MYD88 Polyclonal Antibody is an essential tool for researchers investigating the role of MYD88 in immune response modulation and its potential as a therapeutic target in disease intervention. Its utility in immunology and cancer research makes it a versatile and valuable addition to any laboratory studying immune signaling pathways.
Product Name:
MyD88 Rabbit Polyclonal Antibody
SKU:
CAB16889
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MyD88 (NP_002459.2).
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4615
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse spleen, using MyD88 Rabbit pAb (CAB16889) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
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