The MYD88 Polyclonal Antibody (CAB0980) is a valuable tool for researchers studying MYD88, a key adaptor protein involved in the Toll-like receptor signaling pathway. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting MYD88 in human samples, making it a reliable choice for Western blot applications. By binding to MYD88 protein, this antibody enables precise detection and analysis in various cell types, facilitating research in immunology and inflammation.MYD88 is a crucial player in the immune response, mediating signaling cascades that lead to the activation of inflammatory pathways.
Dysregulation of MYD88 signaling has been implicated in various diseases, including cancer, infectious diseases, and autoimmune disorders. By shedding light on the role of MYD88 in these conditions, researchers can uncover potential therapeutic targets and develop novel treatments to modulate immune responses effectively.Overall, the MYD88 Polyclonal Antibody (CAB0980) is a valuable tool for investigating the function and regulation of MYD88 in different biological contexts, providing insights that can advance our understanding of inflammatory diseases and guide the development of targeted therapies.
Product Name:
MyD88 Rabbit Polyclonal Antibody
SKU:
CAB0980
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 20-140 of human MyD88 (NP_002459.2).
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4615
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MyD88 Rabbit pAb (CAB0980) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
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