The MYD88 Polyclonal Antibody is a research tool designed for studying MYD88, a crucial adaptor protein involved in the innate immune response. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to MYD88 protein, researchers can detect and analyze its expression in a variety of cell types, making it an essential tool for studies in immunology, infectious diseases, and cancer research.MYD88 is a key player in signaling pathways triggered by Toll-like receptors and interleukin-1 receptors, leading to the activation of inflammatory responses and immune defense mechanisms.
Dysregulation of MYD88 signaling has been implicated in various diseases, including autoimmune disorders, inflammatory conditions, and certain types of cancer. Understanding the function of MYD88 is crucial for developing targeted therapies that modulate immune responses and combat disease progression.Overall, the MYD88 Polyclonal Antibody offers researchers a reliable and specific tool for investigating the role of MYD88 in health and disease, ultimately contributing to advancements in the fields of immunology and therapeutic development.
Product Name:
MyD88 Polyclonal Antibody
SKU:
CAB21499
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human MyD88 (NP_002459.2).
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4615
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MyD88 antibody (CAB21499) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
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