The MYD88 Polyclonal Antibody (CAB0786) is a valuable tool for researchers studying the MYD88 protein, a critical signaling molecule involved in the innate immune response. This antibody, derived from rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the MYD88 protein, researchers can detect and analyze its expression in various cell types, making it an essential component in studies related to immunology, infectious diseases, and cancer research.MYD88 plays a crucial role in the activation of inflammatory pathways in response to pathogens, making it a key player in the body's defense against infections.
Dysregulation of MYD88 signaling has been implicated in various diseases, including autoimmune disorders, inflammatory conditions, and certain types of cancer. By understanding the function of MYD88 and its downstream signaling pathways, researchers can develop targeted therapies to modulate immune responses and treat these diseases effectively.Overall, the MYD88 Polyclonal Antibody (CAB0786) provides researchers with a valuable tool to study the role of MYD88 in health and disease, paving the way for advancements in immunotherapy and precision medicine.
Product Name:
MyD88 Rabbit Polyclonal Antibody
SKU:
CAB0786
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 60-309 of human MyD88 (NP_002459.2).
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4615
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from A-549 cells, using MyD88 Rabbit pAb (CAB0786) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
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