The MYC Polyclonal Antibody (CAB11394) is a valuable tool for researchers studying the MYC protein, a key regulator of cell proliferation, growth, and apoptosis. This antibody, produced in rabbits, exhibits high reactivity with human samples, making it a reliable choice for Western blot applications.The MYC protein plays a crucial role in various cellular processes, including cell cycle progression and metabolism, making it a significant target for cancer research. By binding to the MYC protein, this antibody allows for the detection and analysis of MYC levels in different cell types, providing insights into its functions and potential therapeutic implications.
Research involving MYC has implications for understanding cancer development, progression, and treatment. By studying the activity of MYC, researchers can gain valuable insights into the mechanisms that drive tumorigenesis and identify potential targets for therapeutic interventions aimed at inhibiting MYC-related pathways.
Product Name:
c-Myc Rabbit Polyclonal Antibody
SKU:
CAB11394
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 354-453 of human c-Myc (NP_001341799.1).
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.
Purification Method:
Affinity purification
Gene ID:
4609
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded mouse liver using c-Myc Rabbit pAb (CAB11394) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
