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Myc (Phospho-Thr58) Transcription Factor Activity Assay

SKU:
TFAB00037
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
Myc (Phospho-Thr58)
Reactivity:
Human
Mouse
Rat
€599
Frequently bought together:

Description

system_update_altDatasheet

Myc (Phospho-Thr58)Transcription Factor Activity Assay

The MYC Phospho-Thr58 Transcription Factor Activity Assay is a highly sensitive and specific assay designed to measure the transcriptional activity of MYC, a key regulator of cell proliferation and growth. This assay is ideal for studying the role of MYC in various diseases, including cancer, as aberrant MYC activity is often associated with uncontrolled cell growth.This assay kit provides accurate and reproducible results, making it suitable for a wide range of research applications.

By measuring the phosphorylation of MYC at threonine 58, researchers can gain valuable insights into the activity of this important transcription factor and its role in regulating gene expression.Overall, the MYC Phospho-Thr58 Transcription Factor Activity Assay is a valuable tool for studying MYC signaling pathways and identifying potential therapeutic targets for diseases driven by dysregulated MYC activity.

Product Name:Myc (Phospho-Thr58) Transcription Factor Activity Assay
Product Code:TFAB00037
Target:Myc (Phospho-Thr58)
Synonyms:Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64
Reactivity:Human, Mouse, Rat
Sample Types:Nuclear or cell lysates

The Assay Genie Myc (Phospho-Thr58) transcription factor activity assay allows for the detection and qualitative analysis of Myc (Phospho-Thr58) active transcription factors in eukaryotic nuclear or cell lysates.

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.
UniProt Protein Details:

Protein type:DNA-binding; Nucleolus; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 8q24.21

Cellular Component: nucleoplasm; protein complex; nucleolus; nucleus; cytosol

Molecular Function:protein dimerization activity; protein binding; DNA binding; protein complex binding; transcription factor binding; transcription factor activity

Biological Process: oxygen transport; cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; chromosome organization and biogenesis; positive regulation of fibroblast proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; response to gamma radiation; cell cycle arrest; response to drug; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; regulation of telomere maintenance; transcription, DNA-dependent; MAPKKK cascade; negative regulation of cell division; negative regulation of stress-activated MAPK cascade; negative regulation of monocyte differentiation; chromatin remodeling; ureteric bud branching; regulation of gene expression; negative regulation of fibroblast proliferation; energy reserve metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; positive regulation of epithelial cell proliferation; negative regulation of apoptosis

Disease: Burkitt Lymphoma

NCBI Summary:The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P01106
NCBI GenInfo Identifier:127619
NCBI Gene ID:4609
NCBI Accession:P01106.1
UniProt Secondary Accession:P01106,P01107, Q14026, A8WFE7,
UniProt Related Accession:P01106
Molecular Weight:439
NCBI Full Name:Myc proto-oncogene protein
NCBI Synonym Full Names:v-myc avian myelocytomatosis viral oncogene homolog
NCBI Official Symbol:MYC  
NCBI Official Synonym Symbols:MRTL; MYCC; c-Myc; bHLHe39  
NCBI Protein Information:myc proto-oncogene protein; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor
UniProt Protein Name:Myc proto-oncogene protein
UniProt Synonym Protein Names:Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
Protein Family:Myc protein
UniProt Gene Name:MYC  
UniProt Entry Name:MYC_HUMAN
AntibodiesELISA Kits
Anti-c-Myc Mouse Monoclonal Antibody (CAB11029)Human c-myc (c-myc Oncogene Product) ELISA Kit (HUES01900)
Anti-MYC Antibody (CAB11394)Myc (Phospho-Ser62) Transcription Factor Activity Assay
Anti-c-Myc Antibody (CAB1309)MYC Transcription Factor Activity Assay
Anti-c-Myc Antibody (CAB17332)
Anti-c-Myc Antibody [KO Validated] (CAB19032)

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