The MYBPC3 Polyclonal Antibody (CAB12351) is a crucial tool for researchers studying MYBPC3, a protein commonly associated with inherited heart conditions. This antibody, produced through rabbit immunization, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the MYBPC3 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential tool for studies in cardiology and genetic heart disorders.MYBPC3, or myosin binding protein C3, plays a significant role in regulating cardiac muscle function and contraction. Mutations in the MYBPC3 gene are known to cause various forms of familial hypertrophic cardiomyopathy, a condition characterized by an enlarged and thickened heart muscle.
By investigating the function and expression of MYBPC3, researchers can gain valuable insights into the pathogenesis of heart diseases and potential therapeutic avenues for treatment.The MYBPC3 Polyclonal Antibody is a valuable resource for researchers seeking to understand the molecular mechanisms underlying heart conditions and exploring targeted therapies for individuals with genetic predispositions to cardiac disorders. Its high specificity and reliability make it an essential component of any study focusing on MYBPC3 and its role in cardiovascular health.
Product Name:
MYBPC3 Rabbit Polyclonal Antibody
SKU:
CAB12351
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-400 of human MYBPC3 (NP_000247.2).
A band, C zone, cardiac myofibril, cytosol, sarcomere, striated muscle myosin thick filament
Calculated MW:
141kDa
Observed MW:
170kDa
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3 is expressed exclusively in heart muscle and is a key regulator of cardiac contraction. Mutations in this gene are a frequent cause of familial hypertrophic cardiomyopathy.
Purification Method:
Affinity purification
Gene ID:
4607
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from rat heart, using MYBPC3 Rabbit pAb (CAB12351) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
