MYBL2 Antibody (PACO02919)
- SKU:
- PACO02919
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MYBL2 Antibody (PACO02919)
The MYBL2 Polyclonal Antibody (PAC002919) is a valuable tool for researchers studying the MYBL2 protein, which plays a key role in cell cycle progression and regulation. This antibody, produced in rabbits, is highly specific to MYBL2 and has been validated for use in Western blot applications. By binding to the MYBL2 protein, this antibody allows for the detection and analysis of MYBL2 expression in various cell types, making it an ideal choice for research in oncology and cell biology.MYBL2, also known as B-Myb, is a transcription factor that is essential for the control of cell proliferation and differentiation.
Dysregulation of MYBL2 has been implicated in various cancers, making it a promising target for cancer therapy research. By studying MYBL2 expression and activity, researchers can gain insight into the mechanisms underlying cancer development and potentially identify new therapeutic targets for treatment.Overall, the MYBL2 Polyclonal Antibody is a valuable tool for scientists investigating the role of MYBL2 in cellular processes and cancer biology. Its specificity and reliability make it an essential reagent for any lab conducting research in these areas.
| Antibody Name: | MYBL2 Antibody |
| Antibody SKU: | PACO02919 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from human B-Myb around the non-phosphorylation site of S577. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | MYBL2; BMYB; Myb-related protein B; B-Myb; Myb-like protein 2 |
| UniProt Protein Function: | B-Myb: a transcription factor involved in cell cycle progression. Phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 20q13.1 Cellular Component: nucleoplasm Molecular Function:protein binding; chromatin binding; transcription factor activity Biological Process: transcription, DNA-dependent; regulation of cell cycle; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; G2/M transition of mitotic cell cycle |
| NCBI Summary: | The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013] |
| UniProt Code: | P10244 |
| NCBI GenInfo Identifier: | 127584 |
| NCBI Gene ID: | 4605 |
| NCBI Accession: | P10244.1 |
| UniProt Secondary Accession: | P10244,Q53F07, B2RBS5, B7Z8D9, F8W6N6, |
| UniProt Related Accession: | P10244 |
| Molecular Weight: | 75,865 Da |
| NCBI Full Name: | Myb-related protein B |
| NCBI Synonym Full Names: | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| NCBI Official Symbol: | MYBL2Â Â |
| NCBI Official Synonym Symbols: | BMYB; B-MYBÂ Â |
| NCBI Protein Information: | myb-related protein B; myb-like protein 2; v-myb myeloblastosis viral oncogene homolog-like 2 |
| UniProt Protein Name: | Myb-related protein B |
| UniProt Synonym Protein Names: | Myb-like protein 2 |
| Protein Family: | Myb-related protein |
| UniProt Gene Name: | MYBL2Â Â |
| UniProt Entry Name: | MYBB_HUMAN |
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