The MXI1 Polyclonal Antibody (CAB6661) is a crucial tool for researchers studying MXI1, a transcription factor with important roles in cell growth and differentiation. This antibody, raised in rabbits, is highly specific to human MXI1 protein and is validated for use in applications such as Western blotting. By binding to MXI1, this antibody allows for precise detection and analysis of MXI1 expression in a variety of cell types, making it an essential tool for studies in cancer biology and developmental biology.MXI1 is known to function as a tumor suppressor by inhibiting the activity of Myc oncoproteins, making it a key player in regulating cell proliferation and tumorigenesis.
Research on MXI1 has important implications for understanding the molecular mechanisms underlying cancer development and progression, as well as for identifying potential therapeutic targets for cancer treatment. By using the MXI1 Polyclonal Antibody, researchers can gain valuable insights into the functions of MXI1 and its potential as a target for cancer therapy.
Product Name:
MXI1 Rabbit Polyclonal Antibody
SKU:
CAB6661
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 76-295 of human MXI1 (NP_569157.2).
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
Purification Method:
Affinity purification
Gene ID:
4601
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse brain, using MXI1 antibody (CAB6661) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
