MXI1 Rabbit Polyclonal Antibody (CAB6661)
- SKU:
- CAB6661
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | MXI1 Rabbit Polyclonal Antibody |
SKU: | CAB6661 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 76-295 of human MXI1 (NP_569157.2). |
Sequence: | LLEA ASYL EQIE KENK KCEH GYAS SFPS MPSP RLQH SKPP RRLS RAQK HSSG SSNT STAN RSTH NELE KNRR AHLR LCLE RLKV LIPL GPDC TRHT TLGL LNKA KAHI KKLE EAER KSQH QLEN LERE QRFL KWRL EQLQ GPQE MERI RMDS IGST ISSD RSDS EREE IEVD VEST EFSH GEVD NIST TSIS DIDD HSSL PSIG SDEG YSSA SVKL SFTS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | MXI; MAD2; MXD2; bHLHc11; MXI1 |
Positive Sample: | Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 26kDa |
Observed MW: | 30kDa |
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
Purification Method: | Affinity purification |
Gene ID: | 4601 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |