MXI1 Rabbit Polyclonal Antibody (CAB12098)
- SKU:
- CAB12098
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | MXI1 Rabbit Polyclonal Antibody |
SKU: | CAB12098 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 170-295 of human MXI1 (NP_569157.2). |
Sequence: | HTTL GLLN KAKA HIKK LEEA ERKS QHQL ENLE REQR FLKW RLEQ LQGP QEME RIRM DSIG STIS SDRS DSER EEIE VDVE STEF SHGE VDNI STTS ISDI DDHS SLPS IGSD EGYS SASV KLSF TS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | MXI; MAD2; MXD2; bHLHc11; MXI1 |
Positive Sample: | U-87MG,A-549,HepG2,Mouse brain,Rat heart,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 26kDa |
Observed MW: | 30kDa |
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
Purification Method: | Affinity purification |
Gene ID: | 4601 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |