The MXD4 Polyclonal Antibody (CAB16485) is a valuable tool for researchers studying the MXD4 protein, a transcription factor implicated in various biological processes, including cell proliferation and differentiation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the MXD4 protein, this antibody enables precise detection and analysis in a variety of cell types, making it suitable for investigations in molecular biology and cancer research.
MXD4, also known as Max dimerization protein 4, functions as a transcriptional repressor and plays a crucial role in the regulation of gene expression involved in cell cycle control and development. The involvement of MXD4 in these processes makes it an intriguing target for research on diseases related to abnormal cell growth and differentiation, such as cancer. By elucidating the function of MXD4, researchers may uncover potential therapeutic strategies for targeting aberrant gene expression in these pathological conditions.
Product Name:
MXD4 Rabbit Polyclonal Antibody
SKU:
CAB16485
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 110-209 of human MXD4 (NP_006445.1).
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.
Purification Method:
Affinity purification
Gene ID:
10608
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse lung, using MXD4 Rabbit pAb (CAB16485) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
