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MVK Monoclonal Antibody [PAT14F6A] (CPAB0175)

SKU:
CPAB0175
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG3
Clone:
PAT14F6A
Applications:
WB
ELISA
€149
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Description

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MVK Monoclonal Antibody [PAT14F6A] (CPAB0175)

The MVK Polyclonal Antibody (CPAB0175) is a crucial tool for research involving the mevalonate kinase (MVK) protein, a key enzyme in the mevalonate pathway essential for cholesterol biosynthesis. This antibody, produced in rabbits, exhibits high reactivity with human MVK samples and has been validated for use in Western blot applications. By binding to the MVK protein, this antibody enables precise detection and analysis in various cell types, making it ideal for studies in lipid metabolism, cardiovascular disease, and other related research fields.MVK is a critical enzyme involved in the synthesis of isoprenoids, a class of molecules necessary for cellular functions such as membrane integrity, signaling, and protein prenylation. Dysregulation of the mevalonate pathway, including abnormalities in MVK activity, has been linked to various diseases, including mevalonate kinase deficiency (MKD) and hyperimmunoglobulinemia D syndrome (HIDS).

Research on MVK function and regulation is crucial for understanding these conditions and developing targeted therapeutic strategies for patients affected by them.By using the MVK Polyclonal Antibody (CPAB0175) in your research, you can gain valuable insights into the role of MVK in health and disease, advancing our understanding of lipid metabolism and its impact on human health. Its specificity and reliability make it a valuable tool for researchers investigating the mevalonate pathway and its implications in various physiological and pathological processes

Product Name:MVK Antibody
Product Sku:CPAB0175
Size:5μg
Host Species:Mouse
Immunogen:Anti-human MVK mAb, clone PAT14F6A, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human MVK protein 1-396 amino acids  purified from Ecoli.
Clone:PAT14F6A.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:MVK antibody was purified by protein-A affinity chromatography.
Isotype:IgG3
Background:MVK is a member of the GHMP kinase family. Mevalonate is a vital mediator, and MVK an important early enzyme, in isoprenoid and sterol synthesis. MVK deficiency can result in gene mutation associated with Mevalonic aciduria, an illness which causes psychomotor retardation, failure to thrive hepatosplenomegaly, anemia and frequent febrile crises. Mutations in this gene also cause hyperimmunoglobulinaemia D and sporadic fever syndrome, in which the person suffers from recurrent episodes of fever related with lymphadenopathy, skin rash, gastrointestinal dismay and arthralgia.
Synonyms:Mevalonate Kinase (Mevalonic Aciduria), LH Receptor MRNA-Binding Protein, LRBP, Mevalonate Kinase 1, MK, MVLK, EC 2.7.1.36.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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