The MUTYH Polyclonal Antibody (CAB1612) is a valuable tool for researchers studying MUTYH, a DNA repair enzyme crucial for maintaining genomic stability. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it ideal for Western blot applications. By binding specifically to the MUTYH protein, researchers can accurately detect and analyze its expression in a variety of cell types.MUTYH is involved in base excision repair, a key mechanism for correcting oxidative DNA damage. Dysregulation of MUTYH activity has been linked to genomic instability and increased risk of cancer development.
By studying MUTYH expression and function, researchers can gain insights into its role in cancer biology and potentially identify new therapeutic targets for cancer treatment.Overall, the MUTYH Polyclonal Antibody (CAB1612) is a valuable resource for researchers investigating DNA repair mechanisms, cancer biology, and genetic disorders related to MUTYH dysfunction. Its high specificity and sensitivity make it an essential tool for advancing our understanding of MUTYH and its implications in human health and disease.
Product Name:
MUTYH Polyclonal Antibody
SKU:
CAB1612
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-265 of human MUTYH (NP_001041636.1).
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4595
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using MUTYH antibody (CAB1612). Blue: DAPI for nuclear staining.
