MUTYH Polyclonal Antibody (CAB1612)
- SKU:
- CAB1612
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | MUTYH Polyclonal Antibody |
SKU: | CAB1612 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-265 of human MUTYH (NP_001041636.1). |
Sequence: | MTPL VSRL SRLW AIMR KPRA AVGS GHRK QAAS QEGR QKHA KNNS QAKP SACD GLAR QPEE VVLQ ASVS SYHL FRDV AEVT AFRG SLLS WYDQ EKRD LPWR RRAE DEMD LDRR AYAV WVSE VMLQ QTQV ATVI NYYT GWMQ KWPT LQDL ASAS LEEV NQLW AGLG YYSR GRRL QEGA RKVV EELG GHMP RTAE TLQQ LLPG VGRY TAGA IASI AFGQ ATGV VDGN VARV LCRV RAIG ADPS STLV SQQL WGLA QQLV DPAR PGDF N |
Tested Applications: | IHC-P IF/ICC ELISA |
Recommended Dilution: | IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | MYH; MUTYH |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 60kDa |
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 4595 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |