The MUTT Polyclonal Antibody (PACO34714) is a valuable tool for researchers studying MUTT, a protein involved in DNA repair and maintenance. This antibody, produced in rabbits, is highly sensitive and specific for detecting MUTT in human samples, making it an ideal choice for Western blot applications. By targeting the MUTT protein, researchers can gain insights into its function and role in various biological processes.MUTT is a critical enzyme involved in repairing oxidative damage to DNA, making it important for maintaining genomic stability and preventing mutations that can lead to diseases like cancer.
Understanding the mechanisms by which MUTT operates can provide valuable information for developing targeted therapies for cancer treatment and other genetic disorders. The MUTT Polyclonal Antibody is a reliable tool for researchers looking to delve deeper into the functions of this crucial protein.
Antibody Name:
mutT Antibody (PACO34714)
Antibody SKU:
PACO34714
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Escherichia coli
Immunogen:
Recombinant Escherichia coli 8-oxo-dGTP diphosphatase protein (1-129AA)
Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate.
Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate.
UniProt Protein Details:
NCBI Summary:
Nudix hydrolase. [More information is available at EcoGene: EG10626]. dGTP pyrophosphohydrolase (MutT) can catalyze the hydrolysis of all eight canonical nucleotides, but it shows a marked preference for dGTP. [More information is available at EcoCyc: EG10626].
