The MUT Antibody (PAC049014) offered by Assay Genie is a polyclonal antibody designed for research involving the MUT protein. MUT is a crucial enzyme involved in the breakdown of the amino acid methionine. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for use in Western blot applications.The MUT Antibody binds specifically to the MUT protein, enabling accurate detection and analysis in various cell types. This makes it a valuable tool for research in biochemistry and metabolism, particularly in studies related to amino acid metabolism and genetic disorders such as methylmalonic acidemia.
Understanding the function and regulation of the MUT enzyme is essential for developing targeted therapies for individuals with metabolic disorders related to methionine metabolism. This antibody provides researchers with a reliable tool to investigate the role of MUT in health and disease, ultimately contributing to advancements in personalized medicine and treatment strategies.
Antibody Name:
Mut Antibody (PACO49014)
Antibody SKU:
PACO49014
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse Methylmalonyl-CoA mutase, mitochondrial protein (31-748AA)
MUT: Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species. Defects in MUT are the cause of methylmalonic aciduria type mut (MMAM). MMAM is an often fatal disorder of organic acid metabolism. Common clinical features include lethargy, vomiting, failure to thrive, hypotonia, neurological deficit and early death. Two forms of the disease are distinguished by the presence (mut-) or absence (mut0) of residual enzyme activity. Mut0 patients have more severe neurological manifestations of the disease than do MUT- patients. MMAM is unresponsive to vitamin B12 therapy. Belongs to the methylmalonyl-CoA mutase family.Protein type: Carbohydrate Metabolism - propanoate; EC 5.4.99.2; Isomerase; Mitochondrial; Amino Acid Metabolism - valine, leucine and isoleucine degradationCellular Component: mitochondrionMolecular Function: catalytic activity; cobalamin binding; intramolecular transferase activity; isomerase activity; metal ion binding; methylmalonyl-CoA mutase activityBiological Process: homocysteine metabolic process; metabolic process; post-embryonic development
