The Mut Polyclonal Antibody (CAB3969) is a valuable tool for researchers studying mutations in a specific protein. This antibody is designed for use in immunohistochemistry and Western blot applications, allowing for the detection and analysis of mutant protein variants.Raised in rabbits, this antibody is highly reactive with human samples and has been validated for its specificity and sensitivity in detecting mutant forms of the target protein. Its binding specificity enables researchers to characterize mutant protein expression in various cell types, providing insights into the impact of mutations on protein function.
Mutations in proteins can play a critical role in the development and progression of diseases such as cancer and genetic disorders. By using the Mut Polyclonal Antibody, researchers can better understand the molecular mechanisms underlying disease pathology and potentially identify new therapeutic targets for precision medicine approaches.Overall, the Mut Polyclonal Antibody is a valuable tool for investigating the functional consequences of protein mutations, making it an essential component of research in molecular biology, genetics, and personalized medicine.
Product Name:
MUT Rabbit Polyclonal Antibody
SKU:
CAB3969
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 451-750 of human MUT (NP_000246.2).
This gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. Mutations in this gene may lead to various types of methylmalonic aciduria.
Purification Method:
Affinity purification
Gene ID:
4594
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MUT antibody (CAB3969) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
