MUS81 Rabbit Polyclonal Antibody (CAB6818)
- SKU:
- CAB6818
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | MUS81 Rabbit Polyclonal Antibody |
SKU: | CAB6818 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human MUS81 (NP_079404.3). |
Sequence: | MAAP VRLG RKRP LPAC PNPL FVRW LTEW RDEA TRSR RRTR FVFQ KALR SLRR YPLP LRSG KEAK ILQH FGDG LCRM LDER LQRH RTSG GDHA PDSP SGEN SPAP QGRL AEVQ DSSM PVPA QPKA GGSG SYWP ARHS GARV ILLV LYRE HLNP NGHH FLTK EELL QRCA QKSP RVAP GSAR PWPA LRSL LHRN LVLR THQP ARYS LTPE GLEL AQKL AESE GLSL LNVG IGPK EPPG EETA VPGA ASAE LASE AGVQ QQPL ELRP GEYR VLLC VDIG ETRG GGHR PELL RELQ RLHV THTV RKLH VGDF VWVA QETN PRDP ANPG ELVL DHIV ERKR LDDL CSSI IDGR FR |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 |
Synonyms: | SLX3; MUS81 |
Positive Sample: | HeLa,Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus, nucleolus. |
Calculated MW: | 61kDa |
Observed MW: | 70kDa |
This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks.
Purification Method: | Affinity purification |
Gene ID: | 80198 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |