The MUM1 Polyclonal Antibody (PAC07256) is an essential tool for researchers studying the MUM1 protein, which is involved in immune regulation and cell differentiation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the MUM1 protein, this antibody enables precise detection and analysis across various cell types, making it an ideal choice for studies in immunology and cancer research.
MUM1, also known as IRF4, plays a crucial role in regulating immune responses and cell proliferation. Its involvement in gene expression and cell differentiation makes it a valuable target for research into diseases such as cancer and immune-related disorders. Understanding the function of MUM1 is vital for developing therapies that target its activity and modulate immune responses in disease settings.
Antibody Name:
MUM1 Antibody (PACO07256)
Antibody SKU:
PACO07256
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000-1:20000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from MUM1 at AA range: 661-710
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of mouse-kidney mouse-heart mouse-brain cells using MUM1 Polyclonal Antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000.
Synonyms:
melanoma associated antigen (mutated) 1
UniProt Protein Function:
MUM1: Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. Belongs to the MUM1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Cell surface
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytoplasm; nucleus
Molecular Function:nucleosome binding; protein binding
Biological Process: DNA repair; establishment and/or maintenance of chromatin architecture
