The Mug1 Polyclonal Antibody (PACO34378) is a powerful tool for researchers studying Mug1, a key protein involved in cellular signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with Mug1 in human samples and has been validated for use in Western blot applications. By specifically binding to Mug1, this antibody enables precise detection and analysis of Mug1 expression in a variety of cell types, making it an essential asset for investigations in molecular biology and cancer research.Mug1, also known as a crucial regulator of cellular processes, plays a vital role in orchestrating cell signaling events that govern fundamental cellular functions.
Its involvement in multiple signaling pathways makes it a valuable target for research aiming to unravel the complexities of cell signaling cascades and their impact on various cellular processes. Exploring the functions of Mug1 is essential for illuminating the underlying mechanisms of disease development and progression, particularly in the realms of cancer biology and molecular pathology. Unlocking the mysteries of Mug1 could unveil novel therapeutic strategies for combating cancer and other diseases linked to aberrant cellular signaling.
Antibody Name:
Mug1 Antibody (PACO34378)
Antibody SKU:
PACO34378
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse Murinoglobulin-1 protein (700-910AA)
A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective.lysine or another nucleophilic group on the proteinase, for inhibition to be effective.
Synonyms:
Murinoglobulin-1 (MuG1), Mug1, Mug-1
UniProt Protein Function:
Mug1: A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.Cellular Component: extracellular region; extracellular spaceMolecular Function: endopeptidase inhibitor activity; protease inhibitor activity; serine-type endopeptidase inhibitor activityBiological Process: embryo implantation; negative regulation of peptidase activity
