The MUC7 Polyclonal Antibody (PACO20978) is a valuable tool for researchers studying MUC7, a mucin protein found in saliva and mucosal secretions. This polyclonal antibody, produced in rabbits, is highly specific for human samples and is optimized for use in various applications, including Western blotting and immunohistochemistry.MUC7 plays a crucial role in oral health by protecting the mucosal surfaces in the oral cavity and maintaining microbial balance. Dysregulation of MUC7 expression has been associated with conditions such as Sjogren's syndrome and periodontal disease, making it a target of interest in oral biology research.
By using the MUC7 Polyclonal Antibody, researchers can accurately detect and analyze MUC7 protein levels in different cell types and tissues, furthering our understanding of its function in oral health and disease. This antibody is a valuable tool for studies in dentistry, mucosal biology, and microbiology, providing insights that may lead to the development of novel therapeutic strategies for oral health conditions.
Antibody Name:
MUC7 Antibody (PACO20978)
Antibody SKU:
PACO20978
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MUC7
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20978(MUC7 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acid, . This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.
Synonyms:
mucin 7, secreted
UniProt Protein Function:
Function: May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.2 PublicationsManual assertion based on experiment in:Ref.5
NCBI Summary:
This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.[provided by RefSeq, Feb 2009]
