The MUC3A Polyclonal Antibody (PACO18715) is a valuable tool for research focusing on MUC3A, a mucin glycoprotein that is involved in the protection and lubrication of epithelial surfaces. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the MUC3A protein, researchers can easily detect and analyze its expression in various cell types, making it ideal for studies in mucin biology and gastrointestinal research.
MUC3A is known for its role in maintaining mucosal integrity and barrier function, as well as its potential involvement in mucosal defense mechanisms. Understanding the functions and regulation of MUC3A can provide insights into various gastrointestinal disorders, such as inflammatory bowel disease, colorectal cancer, and gastric mucosal lesions. This antibody can aid in exploring the physiological and pathological roles of MUC3A, paving the way for potential therapeutic interventions targeting mucin-related diseases.
Antibody Name:
MUC3A Antibody (PACO18715)
Antibody SKU:
PACO18715
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MUC3A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18715(MUC3A Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18715(MUC3A Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation.
Synonyms:
mucin 3A, cell surface associated
UniProt Protein Function:
MUC3A: Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 7q22Cellular Component: Golgi lumen; extracellular region; integral to membraneMolecular Function: extracellular matrix structural constituent; extracellular matrix constituent, lubricant activityBiological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; post-translational protein modificationDisease: Inflammatory Bowel Disease 11
UniProt Protein Details:
NCBI Summary:
The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]).[supplied by OMIM, Aug 2008]
