The MUC2 Rabbit Monoclonal Antibody (CAB4767) is a valuable tool for researchers investigating Mucin 2, a key mucin protein involved in mucosal protection and barrier function in the gastrointestinal tract. This highly specific antibody, generated from rabbit monoclonal sources, is optimized for detecting MUC2 in human samples and is suitable for applications such as Western blotting.Mucin 2 is a major component of the mucus layer that protects the gut epithelium from pathogens, toxins, and mechanical damage.
Dysregulation of MUC2 expression or function is associated with various gastrointestinal disorders, including inflammatory bowel disease and colorectal cancer. By using this antibody, researchers can gain insights into the role of MUC2 in gut health and disease, paving the way for potential therapeutic interventions targeting mucosal integrity and barrier function.
Product Name:
MUC2 Rabbit Monoclonal Antibody
SKU:
CAB4767
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 5000-5100 of human MUC2 (Q02817).
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis.
Purification Method:
Affinity purification
Gene ID:
4583
Clone Number:
ARC1012
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using MUC2 Rabbit mAb (CAB4767) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
