The MUC2 Polyclonal Antibody (CAB14659) is a valuable tool for researchers studying MUC2, a mucin protein that plays a key role in protecting and lubricating the mucosal surfaces of the body. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the MUC2 protein, this antibody allows for the detection and analysis of MUC2 expression in various cell types, making it ideal for studies in mucosal biology, gastrointestinal health, and diseases related to mucin dysfunction.MUC2 is a major component of the mucus layer that lines the epithelial surfaces of the respiratory, gastrointestinal, and reproductive tracts, providing a barrier against pathogens and environmental insults.
Dysregulation of MUC2 expression and function has been implicated in a variety of diseases, including inflammatory bowel disease, cystic fibrosis, and certain cancers. By investigating the role of MUC2 in these conditions, researchers can gain insights into disease pathogenesis and identify potential therapeutic targets for intervention. The MUC2 Polyclonal Antibody is a valuable tool for advancing our understanding of mucin biology and its implications for human health.
Product Name:
MUC2 Rabbit Polyclonal Antibody
SKU:
CAB14659
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 850-1270 of human MUC2 (NP_002448.4).
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis.
Purification Method:
Affinity purification
Gene ID:
4583
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using MUC2 Rabbit pAb (CAB14659) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
