The MUC1 Rabbit Monoclonal Antibody (CAB19081) is a vital tool for researchers studying MUC1, a transmembrane glycoprotein associated with various cancers, including breast, ovarian, and pancreatic cancer. This antibody, developed using rabbit monoclonal technology, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot and immunohistochemistry applications.MUC1 plays a pivotal role in cancer progression and metastasis by promoting tumor cell survival, proliferation, and immune evasion.
Its aberrant expression has been linked to poor patient prognosis, making it a promising target for anticancer therapies. The MUC1 Rabbit Monoclonal Antibody enables precise detection and characterization of MUC1 protein in tumor tissues and cell lines, facilitating research into novel treatment strategies and diagnostic markers for cancer.
Product Name:
MUC1 Rabbit Monoclonal Antibody
SKU:
CAB19081
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1156-1255 of human MUC1 (P15941).
Apical cell membrane, Cell membrane, Cytoplasm, Nucleus, Secreted, Single-pass type I membrane protein.
Calculated MW:
122kDa
Observed MW:
25kDa/200kDa
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4582
Clone Number:
ARC0352
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung, using MUC1 Rabbit mAb (CAB19081) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
