The MUC1 Polyclonal Antibody (CAB0333) is a valuable tool for research involving MUC1, a protein known for its involvement in cell adhesion and signaling pathways. This antibody, raised in rabbits, demonstrates high reactivity with human samples and is validated for use in various applications, including Western blotting.MUC1, also known as mucin 1, is a glycoprotein that is overexpressed in many types of cancer, making it a potential target for cancer therapy development. Its role in tumor progression and metastasis makes it a molecule of interest for researchers studying cancer biology and potential treatments.
By utilizing the MUC1 Polyclonal Antibody, researchers can detect and analyze MUC1 protein levels in different cell types, aiding in the understanding of its function in cancer cells and its potential as a biomarker for cancer diagnosis and treatment. This antibody is an essential tool for studies in oncology and translational research focused on improving cancer therapies and patient outcomes.
Product Name:
MUC1 Rabbit Polyclonal Antibody
SKU:
CAB0333
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1182-1255 of human MUC1 (P15941).
Apical cell membrane, Cell membrane, Cytoplasm, Nucleus, Secreted, Single-pass type I membrane protein.
Calculated MW:
122kDa
Observed MW:
23-30kDa
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4582
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using MUC1 Rabbit pAb (CAB0333) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
