The MUC1 Polyclonal Antibody is a valuable tool for research involving MUC1, a cell surface glycoprotein associated with cancer progression and metastasis. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including immunofluorescence and immunohistochemistry.MUC1, also known as mucin 1, is overexpressed in many types of cancer, making it a promising target for diagnostic and therapeutic research.
Its role in tumor cell adhesion, migration, and immune evasion makes it a key focus in oncology studies. By targeting MUC1 with this polyclonal antibody, researchers can analyze its expression and localization in cancer cells, paving the way for the development of novel treatments and biomarkers in cancer therapy.
Product Name:
MUC1 Polyclonal Antibody
SKU:
CAB21726
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MUC1 (P15941).
Apical cell membrane, Cell membrane, Cytoplasm, Nucleus, Secreted, Single-pass type I membrane protein.
Calculated MW:
122kDa
Observed MW:
Refer to figures
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4582
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using MUC1 Rabbit pAb (CAB21726) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
