The MTTP Polyclonal Antibody (CAB1746) is a crucial tool for researchers studying Microsomal Triglyceride Transfer Protein (MTTP), a key player in lipid metabolism and fat absorption. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. It binds specifically to the MTTP protein, allowing for accurate detection and analysis in various cell types.MTTP is vital for the assembly and secretion of very low-density lipoproteins (VLDL) and chylomicrons, which are essential for transporting fats throughout the body.
Dysregulation of MTTP has been linked to various metabolic disorders, making it a promising target for research in obesity, cardiovascular diseases, and lipid-related disorders. Understanding the role of MTTP can lead to the development of novel therapeutic strategies for these conditions.Overall, the MTTP Polyclonal Antibody is a valuable tool for researchers investigating the intricate mechanisms of lipid metabolism and its implications in human health. Its high specificity and reliability make it an ideal choice for studies in biochemistry, metabolism, and related fields.
Product Name:
MTTP Rabbit Polyclonal Antibody
SKU:
CAB1746
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 550-650 of human MTTP (NP_000244.2).
Sequence:
SKIV RRVL KEMV AHNY DRF
Tested Applications:
WBIF/ICCELISA
Recommended Dilution:
WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200
Synonyms:
ABL; MTP; MTTP
Positive Sample:
Mouse liver,Rat small intestine
Conjugate:
Unconjugated
Cellular Localization:
Endoplasmic reticulum.
Calculated MW:
99kDa
Observed MW:
99kDa
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
Purification Method:
Affinity purification
Gene ID:
4547
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MTTP antibody (CAB1746) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
