The MTRR Polyclonal Antibody (CAB1462) is a valuable tool for research involving MTRR, a protein involved in the methionine cycle and crucial for DNA methylation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in applications such as Western blotting. By targeting the MTRR protein, researchers can analyze its expression and function in various cell types, making it an essential tool for studies in genetics, epigenetics, and cancer research.MTRR, also known as 5-methyltetrahydrofolate-homocysteine methyltransferase reductase, plays a vital role in maintaining proper levels of methyl groups for DNA methylation and synthesis.
Dysregulation of MTRR has been linked to conditions such as neural tube defects, cardiovascular disease, and cancer, making it a key target for investigating disease mechanisms and potential therapeutic interventions. By understanding the role of MTRR, researchers can uncover new insights into the molecular processes underlying these disorders and develop targeted treatments for patients in need.
Product Name:
MTRR Rabbit Polyclonal Antibody
SKU:
CAB1462
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-230 of human MTRR (NP_002445.2).
This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4552
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MTRR Rabbit pAb (CAB1462) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
