The mTOR Polyclonal Antibody (CAB11355) is a valuable tool for researchers studying the mammalian target of rapamycin (mTOR) signaling pathway. This pathway plays a crucial role in cell growth, proliferation, and metabolism, making it a key target for studying various diseases, including cancer, diabetes, and neurodegenerative disorders.This polyclonal antibody, produced in rabbits, is highly specific and reactive to human samples, making it an ideal choice for Western blot applications. By binding to the mTOR protein, this antibody allows for the detection and analysis of mTOR expression in different cell types, providing insights into cellular processes regulated by this signaling pathway.
Understanding the function and regulation of mTOR is essential for developing targeted therapies for diseases influenced by dysregulated mTOR signaling. By using the mTOR Polyclonal Antibody (CAB11355), researchers can further explore the role of mTOR in disease pathogenesis and potential therapeutic interventions.
Product Name:
mTOR Rabbit Polyclonal Antibody
SKU:
CAB11355
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 2400-2500 of human mTOR (NP_004949.1).
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene.
Purification Method:
Affinity purification
Gene ID:
2475
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using mTOR Rabbit pAb (CAB11355) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
