The MTNR1B Polyclonal Antibody (PAC049782) is a valuable tool for researchers studying the MTNR1B gene, which encodes the melatonin receptor 1B protein. This antibody, produced in rabbits, specifically targets the MTNR1B protein and is highly reactive with human samples. Validated for use in Western blot applications, this antibody allows for the detection and analysis of MTNR1B in various cell types.The melatonin receptor 1B protein is involved in the regulation of circadian rhythms and has been implicated in various biological processes, including sleep-wake cycles, metabolism, and immune function.
Research into the function of MTNR1B is important for understanding its role in health and disease, with implications for conditions such as diabetes, obesity, and sleep disorders.By exploring the activity of MTNR1B, researchers can gain insights into potential therapeutic targets for a range of medical conditions. The MTNR1B Polyclonal Antibody is a valuable tool for investigating the function of this protein and advancing research in the fields of chronobiology, metabolism, and neuroendocrinology.
Immunohistochemistry of paraffin-embedded human eye tissue using PACO49782 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO49782 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human brain tissue using PACO49782 at dilution of 1:100.
Background:
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Synonyms:
Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor), MTNR1B
UniProt Protein Function:
MTNR1B: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1Chromosomal Location of Human Ortholog: 11q21-q22Cellular Component: cytosol; integral to plasma membrane; plasma membraneMolecular Function: G-protein coupled receptor activity; melatonin receptor activity; protein bindingBiological Process: camera-type eye development; cell surface receptor linked signal transduction; circadian rhythm; G-protein signaling, coupled to cyclic nucleotide second messenger; glucose homeostasis; negative regulation of cGMP metabolic process; negative regulation of insulin secretion; negative regulation of neuron apoptosis; negative regulation of transmission of nerve impulse; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of transmission of nerve impulse; positive regulation of vasodilation; reduction of cytosolic calcium ion concentration; regulation of insulin secretion; synaptic transmissionDisease: Diabetes Mellitus, Noninsulin-dependent
UniProt Protein Details:
NCBI Summary:
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]
