The MTNR1B Polyclonal Antibody (PACO06633) is specifically designed for research involving the MTNR1B gene, which encodes the melatonin receptor 1B. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the MTNR1B protein, this antibody allows for the detection and analysis of MTNR1B in various cell types, making it a valuable tool for studies in chronobiology, neurology, and endocrinology.The MTNR1B gene plays a crucial role in mediating the effects of melatonin, a hormone involved in regulating circadian rhythms and sleep-wake cycles.
Research into the function of MTNR1B is essential for understanding its role in various physiological processes, including sleep disorders, mood regulation, and metabolic functions. By targeting MTNR1B, researchers can gain insights into the mechanisms underlying these processes and potentially develop new therapeutic strategies for related disorders.
Antibody Name:
MTNR1B Antibody (PACO06633)
Antibody SKU:
PACO06633
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:5000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the C-terminal region of human MEL-1B-R.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of HELA A549 cells using MEL-1B-R Polyclonal Antibody.
Western Blot analysis of HepG2 cells using MEL-1B-R Polyclonal Antibody.
Synonyms:
MTNR1B; Melatonin receptor type 1B; Mel-1B-R; Mel1b receptor
UniProt Protein Function:
MTNR1B: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1Chromosomal Location of Human Ortholog: 11q21-q22Cellular Component: cytosol; integral to plasma membrane; plasma membraneMolecular Function: G-protein coupled receptor activity; melatonin receptor activity; protein bindingBiological Process: camera-type eye development; cell surface receptor linked signal transduction; circadian rhythm; G-protein signaling, coupled to cyclic nucleotide second messenger; glucose homeostasis; negative regulation of cGMP metabolic process; negative regulation of insulin secretion; negative regulation of neuron apoptosis; negative regulation of transmission of nerve impulse; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of transmission of nerve impulse; positive regulation of vasodilation; reduction of cytosolic calcium ion concentration; regulation of insulin secretion; synaptic transmissionDisease: Diabetes Mellitus, Noninsulin-dependent
UniProt Protein Details:
NCBI Summary:
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]
