The MTMR3 Polyclonal Antibody (CAB10806) is a potent tool for studying the MTMR3 protein, which is involved in regulating cell growth and survival. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the MTMR3 protein, researchers can analyze its expression and function in various cell types, making it an invaluable asset for studies in cell biology and cancer research.MTMR3 plays a crucial role in maintaining cellular homeostasis by regulating processes such as autophagy and cell proliferation.
Dysregulation of MTMR3 has been linked to various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic intervention. Investigating the role of MTMR3 using this antibody can provide valuable insights into the mechanisms underlying these diseases, potentially leading to the development of novel treatment strategies.
Product Name:
MTMR3 Rabbit Polyclonal Antibody
SKU:
CAB10806
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 640-810 of human MTMR3 (NP_066576.1).
This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8897
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type(WT) and MTMR3 knockdown (KD) 293T cells, using [KD Validated] MTMR3 Rabbit pAb(CAB10806) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
