The MTMR2 Polyclonal Antibody (CAB8993) is a valuable tool for researchers studying MTMR2, a protein involved in cellular functions such as membrane trafficking and autophagy. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is specifically validated for use in Western blot applications. By targeting the MTMR2 protein, researchers can effectively detect and analyze its expression in various cell types, making it an ideal choice for studies in cell biology and molecular biology.
MTMR2, a member of the myotubularin-related protein family, plays a crucial role in regulating phosphoinositide metabolism and membrane trafficking processes. Dysregulation of MTMR2 has been linked to various diseases, including neurological disorders and cancer. Therefore, the MTMR2 Polyclonal Antibody is an essential tool for investigating the function of MTMR2 in health and disease, providing valuable insights for drug development and therapeutic targeting strategies.
Product Name:
MTMR2 Rabbit Polyclonal Antibody
SKU:
CAB8993
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 404-643 of human MTMR2 (NP_057240.3).
Cytoplasm, Early endosome membrane, Peripheral membrane protein.
Calculated MW:
73kDa
Observed MW:
65-73kDa
This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8898
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MTMR2 antibody (CAB8993) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
