The MTMR12 Polyclonal Antibody (PAC05949) is specifically designed for research involving MTMR12, a protein phosphatase involved in regulating various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By binding to the MTMR12 protein, this antibody enables accurate detection and analysis in a wide range of cell types, making it a valuable tool for studies in cell biology and signal transduction research.MTMR12, also known as myotubularin-related protein 12, plays a crucial role in cellular signaling pathways by dephosphorylating phosphoinositides and regulating membrane trafficking processes.
Its involvement in these key cellular functions makes it a promising target for research into diseases such as cancer, neurodegenerative disorders, and metabolic diseases. Understanding the functions and mechanisms of MTMR12 can provide valuable insights for the development of novel therapeutic strategies targeting these diseases.
Antibody Name:
MTMR12 Antibody (PACO59449)
Antibody SKU:
PACO59449
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Myotubularin-related protein 12 protein (188-318AA)
Immunofluorescence staining of Hela cells with PACO59449 at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location.
MTMR12: Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffold; Protein phosphatase, tyrosine (non-receptor)Chromosomal Location of Human Ortholog: 5p13.3Cellular Component: cytoplasmMolecular Function: protein binding; phosphoric monoester hydrolase activityBiological Process: dephosphorylation
UniProt Protein Details:
NCBI Summary:
Phosphatidylinositide 3-kinase-derived membrane-anchored phosphatidylinositides, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), regulate diverse cellular processes. The protein encoded by this gene functions as an adaptor subunit in a complex with an active PtdIns(3)P 3-phosphatase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
