The MTF1 Polyclonal Antibody (PAC016715) is a valuable tool for researchers studying metal-regulatory transcription factor 1 (MTF1), a key regulator of metal homeostasis and response to oxidative stress in cells. Raised in rabbits, this antibody demonstrates high reactivity with human samples and has been validated for use in Western blot applications.MTF1 plays a crucial role in responding to changes in intracellular levels of essential metals such as zinc and copper, as well as protecting cells from damage caused by reactive oxygen species. Its involvement in regulating genes related to metal transport, detoxification, and antioxidant defense makes it an intriguing target for investigations into various diseases, including cancer, neurodegenerative disorders, and metal toxicity.
By enabling detection and analysis of MTF1 protein in different cell types, this antibody serves as a valuable tool for researchers in the fields of molecular biology, metal biology, and toxicology. Understanding the function and regulation of MTF1 could provide insights into potential therapeutic strategies for conditions linked to metal dysregulation and oxidative stress.
Antibody Name:
MTFR1 Antibody (PACO16715)
Antibody SKU:
PACO16715
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Fusion protein of human MTFR1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16715(MTFR1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X.
Synonyms:
mitochondrial fission regulator 1
UniProt Protein Function:
May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission ().
UniProt Protein Details:
NCBI Summary:
This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X. [provided by RefSeq, Mar 2009]
