The MTF1 Polyclonal Antibody (PAC016714) is a valuable tool for researchers studying MTF1, a transcription factor involved in metal ion homeostasis and oxidative stress response. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the MTF1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in molecular biology, toxicology, and environmental health.MTF1, also known as metal-regulatory transcription factor 1, is a key player in the cellular response to heavy metal exposure and oxidative stress.
Its role in regulating metallothioneins and other genes involved in metal ion transport and detoxification highlights its importance in maintaining cellular health and protecting against metal-induced toxicity. Research on MTF1 is crucial for understanding the mechanisms of metal toxicity, oxidative stress-related diseases, and potential therapeutic interventions targeting metal ion dysregulation.Overall, the MTF1 Polyclonal Antibody is a valuable tool for researchers interested in unraveling the complexities of metal ion homeostasis and oxidative stress response, offering insights into the molecular mechanisms underlying various diseases and potential therapeutic strategies.
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: A549 cells, HT29 cells, A172 cells, Primary antibody: PACO16714(MTFR1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16714(MTFR1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X.
Synonyms:
mitochondrial fission regulator 1
UniProt Protein Function:
May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission ().
UniProt Protein Details:
NCBI Summary:
This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X. [provided by RefSeq, Mar 2009]
