The MTERF4 Polyclonal Antibody (PAC046738) is a valuable tool for researchers studying MTERF4, a mitochondrial transcription termination factor involved in regulating gene expression in mitochondria. This antibody, produced in rabbits, exhibits high specificity and sensitivity when used in Western blot experiments with human samples.MTERF4 plays a crucial role in modulating mitochondrial gene expression and is essential for maintaining mitochondrial function. Dysregulation of MTERF4 has been linked to various diseases, including neurodegenerative disorders and metabolic syndromes. Research on MTERF4 is vital for understanding mitochondrial biology and developing potential targeted therapies for mitochondrial-related diseases.
The MTERF4 Polyclonal Antibody is an excellent choice for investigating the function and expression of MTERF4 in different cell types and tissues. Its reliability and versatility make it a valuable asset for studies in molecular biology, biochemistry, and mitochondrial research. By utilizing this antibody, researchers can gain valuable insights into the complex role of MTERF4 in mitochondrial gene regulation and its implications in human health and disease.
Western blot. All lanes: MTERF4 antibody at 2 µg/ml. Lane 1: Mouse kidney tissue. Lane 2: HL60 whole cell lysate. Lane 3: A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 44 kDa. Observed band size: 44 kDa..
Immunofluorescent analysis of HepG2 cells using PACO46738 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO46738 at dilution of 1:100.
Background:
Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).
MTERFD2: Belongs to the mTERF family.Chromosomal Location of Human Ortholog: 2q37.3Cellular Component: cytoplasm; mitochondrial large ribosomal subunit; mitochondrionMolecular Function: protein binding; rRNA binding
