The MTCH2 Polyclonal Antibody (CAB12934) is a crucial tool for researchers studying the mitochondrial carrier homolog 2 (MTCH2) protein, a key player in mitochondrial dynamics and metabolism. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, allowing for accurate detection and analysis in Western blot experiments.MTCH2 is involved in various cellular processes, including mitochondrial fission, apoptosis, and metabolism regulation. Dysregulation of MTCH2 has been linked to diseases such as cancer, neurodegenerative disorders, and metabolic syndromes, highlighting its potential as a therapeutic target.
By studying the function and expression of MTCH2 using this polyclonal antibody, researchers can gain valuable insights into the role of mitochondria in health and disease.Overall, the MTCH2 Polyclonal Antibody (CAB12934) is a valuable tool for investigating the intricate functions of the MTCH2 protein and its implications in mitochondrial biology and disease pathology. Its reliable performance and specificity make it an essential asset for researchers in the fields of cell biology, metabolism, and therapeutic development.
Product Name:
MTCH2 Rabbit Polyclonal Antibody
SKU:
CAB12934
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-175 of human MTCH2 (NP_055157.1).
This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons.
Purification Method:
Affinity purification
Gene ID:
23788
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type(WT) and MTCH2 knockout (KO) HeLa(KO) cells, using [KO Validated] MTCH2 Rabbit pAb (CAB12934) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
