The MTAP Polyclonal Antibody (CAB1049) is a valuable tool for researchers studying MTAP, a key enzyme involved in the biosynthesis of methylthioadenosine (MTA) which plays a critical role in various cellular processes including cell proliferation and apoptosis. This antibody, raised in rabbits, has high specificity and sensitivity for human samples, making it ideal for use in Western blot applications.MTAP, also known as methylthioadenosine phosphorylase, is essential for the recycling of MTA and maintaining cellular methylation balance.
Dysregulation of MTAP has been linked to tumorigenesis and poor prognosis in various types of cancer, making it a promising target for cancer therapy and biomarker development. The MTAP Polyclonal Antibody enables researchers to detect and analyze MTAP expression levels in different cell types, providing valuable insights into its role in cancer biology and potential therapeutic interventions.
Product Name:
MTAP Rabbit Polyclonal Antibody
SKU:
CAB1049
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human MTAP (NP_002442.2).
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage pathway of both adenine and methionine. The encoded enzyme is deficient in many cancers. Multiple alternatively spliced transcript variants have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
4507
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from NIH/3T3 cells, using MTAP Rabbit pAb (CAB1049) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
