The MTA1 Polyclonal Antibody (CAB16085) is a vital tool for researchers studying the MTA1 protein, which plays a crucial role in various cellular processes, including gene regulation and cancer progression. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.By targeting the MTA1 protein, this antibody enables the detection and analysis of MTA1 expression in different cell types, making it an essential tool for investigating the role of MTA1 in cancer and other diseases.
Understanding the function of MTA1 is essential for developing targeted therapies that could potentially disrupt cancer progression and other cellular processes influenced by MTA1. Overall, the MTA1 Polyclonal Antibody (CAB16085) is a valuable asset for researchers in the fields of cancer biology, gene regulation, and cellular signaling, providing a reliable tool for studying the functions of MTA1 and its implications for various diseases.
Product Name:
MTA1 Rabbit Polyclonal Antibody
SKU:
CAB16085
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human MTA1 (NP_004680.2).
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9112
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MTA1 antibody (CAB16085) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
