The MT2A Polyclonal Antibody (CAB2018) is a valuable tool for researchers studying metallothionein 2A (MT2A), a protein involved in metal ion homeostasis and detoxification processes in the body. This antibody, raised in rabbits, is highly specific to human MT2A and has been validated for use in Western blot applications.MT2A is known for its role in binding heavy metals like zinc and copper, protecting cells from metal-induced damage and oxidative stress. Dysregulation of MT2A has been linked to various diseases, including cancer, neurodegenerative disorders, and metal poisoning.
By detecting and quantifying MT2A levels in cell samples, researchers can gain valuable insights into the molecular mechanisms underlying these conditions.This antibody enables researchers to explore the expression and localization of MT2A in different cell types, tissues, and experimental conditions, providing a deeper understanding of its biological functions. By studying MT2A, scientists may uncover new therapeutic targets and strategies for treating diseases related to metal toxicity and imbalance.
Product Name:
MT2A Rabbit Polyclonal Antibody
SKU:
CAB2018
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-61 of human MT2A (NP_005944.1).
This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer.
Purification Method:
Affinity purification
Gene ID:
4502
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MT2A Rabbit pAb (CAB2018) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
