The MT-ND1 Polyclonal Antibody (CAB18316) is a vital tool for researchers studying mitochondrial NADH dehydrogenase 1 (MT-ND1), a key enzyme involved in oxidative phosphorylation and energy production in the cell. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting MT-ND1 in human samples, making it suitable for a variety of applications such as Western blotting.MT-ND1 is a subunit of complex I in the mitochondrial electron transport chain, playing a crucial role in generating ATP, the cell's main energy source.
Dysregulation of MT-ND1 has been linked to various diseases, including mitochondrial disorders and certain cancers. By using the MT-ND1 Polyclonal Antibody, researchers can gain insights into the function and regulation of this enzyme, paving the way for potential therapeutic interventions targeting mitochondrial dysfunction-related conditions.
Product Name:
MT-ND1 Rabbit Polyclonal Antibody
SKU:
CAB18316
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 151-251 of human MT-ND1 (YP_003024026.1).
mitochondrial inner membrane, mitochondrial membrane, mitochondrial respiratory chain complex I
Calculated MW:
36kDa
Observed MW:
36kDa
Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrial membrane. Part of mitochondrial respiratory chain complex I. Implicated in several diseases, including MELAS syndrome; neurodegenerative disease (multiple); optic nerve disease (multiple); toxic shock syndrome; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; Parkinson's disease; and multiple sclerosis.
Purification Method:
Affinity purification
Gene ID:
4535
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MT-ND1 Rabbit pAb (CAB18316) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 120s.
