The MT-ND1 Polyclonal Antibody (CAB17967) is designed for research involving MT-ND1, a protein encoded by the mitochondrial gene NADH dehydrogenase subunit 1. This antibody, derived from rabbit polyclonal sources, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the MT-ND1 protein, researchers can detect and analyze its expression in various cell types, providing valuable insights into mitochondrial function and dysfunction.MT-ND1 is a key component of complex I in the mitochondrial electron transport chain, playing a crucial role in ATP production and cellular metabolism.
Dysregulation of MT-ND1 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic conditions. By studying the function and expression of MT-ND1, researchers can gain a better understanding of how mitochondrial dysfunction contributes to these pathologies, potentially leading to the development of novel therapeutic strategies targeting mitochondrial biology.
Product Name:
MT-ND1 Rabbit Polyclonal Antibody
SKU:
CAB17967
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MT-ND1 (YP_003024026.1).
mitochondrial inner membrane, mitochondrial membrane, mitochondrial respiratory chain complex I
Calculated MW:
36kDa
Observed MW:
36kDa
Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrial membrane. Part of mitochondrial respiratory chain complex I. Implicated in several diseases, including MELAS syndrome; neurodegenerative disease (multiple); optic nerve disease (multiple); toxic shock syndrome; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; Parkinson's disease; and multiple sclerosis.
Purification Method:
Affinity purification
Gene ID:
4535
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MT-ND1 Rabbit pAb (CAB17967) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
